Stanley Nattel Selected Research

Atrioventricular Block

1/2022	Rotors anchored by refractory islands drive torsades de pointes in an experimental model of electrical storm.
8/2013	T-type calcium current contributes to escape automaticity and governs the occurrence of lethal arrhythmias after atrioventricular block in mice.
5/2011	Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm.
3/2010	Minimizing repolarization-related proarrhythmic risk in drug development and clinical practice.
10/2008	Model systems for the discovery and development of antiarrhythmic drugs.
7/2008	Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome.
10/2007	Acute and chronic effects of cardiac resynchronization in patients developing heart failure with long-term pacemaker therapy for acquired complete atrioventricular block.
1/2006	Potassium channel subunit remodeling in rabbits exposed to long-term bradycardia or tachycardia: discrete arrhythmogenic consequences related to differential delayed-rectifier changes.

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Stanley Nattel Research Topics

Disease

126	Atrial Fibrillation 05/2023 - 05/2002
45	Heart Failure 04/2024 - 03/2002
41	Cardiac Arrhythmias (Arrythmia) 12/2022 - 09/2002
37	Fibrosis (Cirrhosis) 05/2024 - 11/2003
25	Tachycardia (Tachyarrhythmias) 12/2023 - 05/2002
13	Inflammation (Inflammations) 04/2024 - 10/2004
13	Atrial Remodeling 05/2023 - 05/2002
13	Heart Diseases (Heart Disease) 11/2019 - 07/2005
9	Myocardial Infarction 01/2024 - 04/2007
8	Atrioventricular Block 01/2022 - 01/2006
7	Stroke (Strokes) 03/2024 - 12/2009
7	Cardiomyopathies (Cardiomyopathy) 01/2023 - 09/2006
7	Ventricular Tachycardia 01/2022 - 08/2004
5	Ventricular Fibrillation 01/2022 - 05/2011
5	Left Ventricular Dysfunction 01/2018 - 04/2007
4	Infarction (Infarctions) 04/2022 - 12/2007
4	Coronary Artery Disease (Coronary Atherosclerosis) 10/2021 - 10/2016
4	Cardiomegaly (Heart Hypertrophy) 11/2019 - 12/2008
4	Hypertrophy 10/2019 - 04/2012
3	Cognitive Dysfunction 01/2024 - 12/2009
3	Myocardial Ischemia (Ischemic Heart Diseases) 01/2022 - 02/2004
3	Thromboembolism 01/2021 - 01/2011
3	Ischemia 11/2011 - 01/2007
3	Bradycardia 06/2009 - 01/2006
2	Edema (Dropsy) 04/2024 - 10/2013
2	Infections 12/2022 - 11/2020
2	Neoplasms (Cancer) 04/2022 - 09/2002
2	Hemorrhage 01/2021 - 03/2012
2	Pulmonary Hypertension 01/2021 - 01/2015
2	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 11/2019 - 11/2014
2	Vascular Diseases (Vascular Disease) 01/2019 - 11/2012
2	Acute Coronary Syndrome 01/2017 - 12/2009
2	Torsades de Pointes (Torsade de Pointes) 01/2016 - 08/2004
2	Heart Valve Diseases (Valvular Heart Disease) 10/2015 - 07/2005
2	Cardiac Sudden Death (Sudden Cardiac Arrest) 10/2014 - 04/2004
2	Chronic Renal Insufficiency 10/2014 - 03/2012

Drug/Important Bio-Agent (IBA)

23	Proteins (Proteins, Gene)FDA Link 04/2024 - 04/2004
21	Anti-Arrhythmia AgentsIBA 01/2022 - 03/2003
18	Ion Channels (Ion Channel)IBA 08/2019 - 08/2003
17	CalciumIBA 04/2024 - 06/2008
9	Biomarkers (Surrogate Marker)IBA 04/2024 - 11/2012
9	Messenger RNA (mRNA)IBA 01/2018 - 07/2005
8	CollagenIBA 01/2020 - 02/2007
8	PotassiumIBA 02/2015 - 04/2006
7	ConnexinsIBA 05/2023 - 01/2007
7	Adenosine (Adenocard)FDA LinkGeneric 12/2020 - 09/2013
6	salicylhydroxamic acid (SHAM)IBA 12/2023 - 01/2007
6	AnticoagulantsIBA 11/2018 - 10/2005
5	Vitamin K FDA Link 10/2021 - 03/2012
5	Angiotensin IIIBA 01/2017 - 11/2003
5	dofetilide (Tikosyn)FDA Link 01/2016 - 03/2003
5	Potassium Channels (Potassium Channel)IBA 01/2016 - 07/2005
5	Dronedarone FDA Link 01/2016 - 01/2009
5	Acetylcholine (Acetylcholine Chloride)FDA Link 10/2011 - 06/2007
4	InflammasomesIBA 05/2024 - 11/2018
4	MicroRNAs (MicroRNA)IBA 04/2024 - 02/2014
4	Protein Kinases (Protein Kinase)IBA 01/2020 - 07/2015
4	Sodium Channels (Sodium Channel)IBA 12/2015 - 10/2003
4	Adrenergic Receptors (Adrenergic Receptor)IBA 03/2014 - 03/2002
4	Adenosine Triphosphate (ATP)IBA 11/2011 - 01/2007
4	Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)IBA 03/2006 - 05/2002
3	Reactive Oxygen Species (Oxygen Radicals)IBA 04/2024 - 04/2004
3	SodiumIBA 04/2024 - 01/2011
3	Natriuretic PeptidesIBA 04/2024 - 01/2019
3	RNA (Ribonucleic Acid)IBA 12/2023 - 12/2008
3	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 10/2021 - 01/2017
3	Phosphotransferases (Kinase)IBA 11/2020 - 11/2018
3	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2017 - 07/2011
3	Flecainide (Tambocor)FDA LinkGeneric 01/2011 - 03/2003
3	Sotalol (Sotalol Hydrochloride)FDA LinkGeneric 01/2011 - 09/2003
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 06/2008 - 12/2006
3	Amiodarone (Amiodarona)FDA LinkGeneric 09/2003 - 01/2003
2	beta Adrenergic ReceptorsIBA 04/2024 - 10/2013
2	Myosin Light Chains (Myosin Essential Light Chain)IBA 01/2023 - 10/2017
2	Fish OilsIBA 12/2021 - 10/2014
2	Furylfuramide (AF2)IBA 10/2021 - 11/2018
2	MonocrotalineIBA 01/2021 - 10/2019
2	Protein Kinase CIBA 10/2020 - 10/2011
2	Calcium-Calmodulin-Dependent Protein Kinase Type 2IBA 01/2020 - 09/2008
2	Adenosine Monophosphate (AMP)IBA 01/2020 - 07/2015
2	RivaroxabanIBA 01/2019 - 03/2012
2	Digoxin (Digitek)FDA LinkGeneric 11/2018 - 10/2016
2	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 01/2018 - 03/2014
2	SaltsIBA 10/2017 - 10/2008
2	Platelet-Derived Growth FactorIBA 01/2017 - 04/2008
2	integrin-linked kinaseIBA 08/2015 - 09/2006
2	AutoantibodiesIBA 11/2014 - 10/2006
2	Omega-3 Fatty Acids (Omega 3 Fatty Acids)IBA 10/2014 - 03/2011

Therapy/Procedure

56	Therapeutics 05/2024 - 09/2002
15	Catheter Ablation 01/2022 - 10/2005
12	Catheters 01/2021 - 01/2012
6	Drug Therapy (Chemotherapy) 04/2022 - 03/2003
5	Electric Countershock (Cardioversion) 01/2021 - 01/2006
4	Defibrillators (Defibrillator) 12/2022 - 05/2006
3	Cardiac Resynchronization Therapy 12/2022 - 10/2007
3	Implantable Defibrillators (Implantable Cardioverter-Defibrillator) 01/2022 - 01/2009
2	Biological Therapy 01/2023 - 12/2014
2	Intraperitoneal Injections 01/2021 - 10/2019
2	Radiofrequency Ablation 12/2020 - 01/2008
2	Electrodes (Electrode) 01/2018 - 08/2004